ACERT Core Research & Development

last update:   July 16, 2009

The principal areas of core R&D carried out at ACERT are
        (click on the underlined text to get the most recent/important information)

Pulsed ESR: distance measurements in proteins and aggregates using double quantum coherence (DQC) ESR, to advance our knowledge of structure and function of biomolecules using longer distance constraints, provided by site-directed spin labeling and pulsed ESR distance measurements. Highlights.

Pulsed ESR: two-dimensional Fourier transform ESR, to further develop 2D-ELDOR in the study of the dynamic structure of membranes and of proteins, as well as lipid-protein interactions. Highlights.

ESR microscopy, to establish cw and pulse ESR micro-imaging for biomedical studies of tissues, cells and other bio-samples with micron resolution. Highlights.

High-frequency high-field (HFHF) cw and High-frequency high-field (HFHF) pulsed ESR, to further develop quasi-optical techniques for HFHF-ESR to unravel the complex dynamics in biological systems and, especially, to extend high power pulsed ESR to the mm-wave regime, to benefit from the improved orientational resolution and faster “snapshot” feature at higher frequencies.
cw-HFHF Highlights; pulsed HFHF Highlights

Multifrequency studies, to advance knowledge of dynamics in proteins, DNA, and membranes by a mixture of multifrequency and multidimensional ESR. Highlights.

Protein Dynamics by NMR Highlights

Model and Cell Membrane Dynamics by ESR Highlights

Theoretical and computational methods, to improve the methods for interpreting multifrequency spectra in terms of powerful algorithms based on the stochastic Liouville equation and on molecular dynamics simulations. Highlights.

The Center’s collaborative research projects cover a wide range of biomedical research areas, emphasizing the central role that modern ESR methods can play in contemporary biomedical sciences.

Highlights Index