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National Biomedical Resource
for Advanced Electron Spin Resonance Spectroscopy

Our research is supported by grant 1R24GM146107 from the National Institute of General Medical Sciences (NIGMS), part of the National Institutes of Health.

Recent ACERT Research Highlights from Service and Collaborations

Membrane Binding Induces Distinct Structural Signatures in the Mouse Complexin-1C-Terminal Domain
Emily M. Grasso, Mayu S. Terakawa, Alex L. Lai, Ying Xue Xie, Trudy F. Ramlall, Jack H. Freed, and David Eliezer

Novel Class of Broad-Spectrum Antivirals Improves Enveloped Virus Vaccine Development
Armando Pacheco, Isaac A. Monreal, David W. Buchholz, Shi Xu, Erik M. Contreras, Brian Imbiakha, Julie Sahler, Mason Jager, Alex Liqi Lai, Brandan Cook, Elshan Ralalage, Qian Liu, Yao Yu Yeo, Andrew Ma, Juana L. Zamora, Niraj K. Shil, Sara Jones-Burrage, Suzanne M. Pritchard, Chuntao Yang, Yu Zhao, Zeinab J. Mohamed, Cheyan Xu, Susan Daniel, Michael J. Jung, Gerlinde Van de Walle, Avery August, Suchetana T. Mukhopadhyay, Masako Shimamura, Alan Goodman, Michele Hardy, Santanu Bose, Anthony V. Nicola, Jack H. Freed, Jace W. Jones, Ming Xian, Hector C. Aguilar.

Lewis Acid-Assisted Reduction of Nitrite to Nitric and Nitrous Oxide via the Elusive Nitrite Radical Dianion
Valiallah Hosseininasab, Ida M. DiMucci, Pokhraj Ghosh, Jeffery A. Bertke, Siddarth Chandrasekaran, Charles J. Titus, Dennis Nordlund, Jack H. Freed, Kyle M. Lancaster, and Timothy H. Warren.

Negatively Charged Residues in the Membrane Ordering Activity of SARS-1 and SARS-2 Fusion Peptides
Alex L. Lai, Jack H. Freed.

Highly Basic Clusters in the Herpes Simplex Virus 1 Nuclear Egress Complex Drive Membrane Budding by Inducing Lipid Ordering
Michael K. Thorsen, Alex Lai, Michelle W. Lee, David P. Hoogerheide, Gerard C. L. Wong, Jack H. Freed, Ekaterina E. Heldwein.

Theory and Least Squares Fitting of CW ESR Saturation Spectra Using the MOMD Model
Pranav Gupta, Boris Dzikovski, and Jack H. Freed.

Dph3 Enables Aerobic Diphthamide Biosynthesis by Donating One Iron Atom to Transform a [3Fe–4S] to a [4Fe–4S] Cluster in Dph1–Dph2
Yugang Zhang, Dan Su, Boris Dzikovski, Sean H. Majer, Rachael Coleman, Siddarth Chandrasekaran, Michael K. Fenwick, Brian R. Crane, Kyle M. Lancaster, Jack H. Freed, Hening Lin.

Engineered Chemotaxis Core Signaling Units Studied by Pulse-Dipolar ESR Indicate A Constrained Kinase-Off State
Alise R. Muok, Teck Khiang Chua, Madhur Srivastava, Wen Yang, Zach Maschmann, Petr P. Borbat, Jenna Chong, Sheng Zhang, Jack H. Freed, Ariane Briegel, and Brian R. Crane

Microsecond Exchange Processes Studied by Two-Dimensional ESR at 95 GHz
Boris Dzikovski, Valery V. Khramtsov, Siddarth Chandrasekaran, Curt Dunnam, Meera Shah, and Jack H. Freed.

Insights into Histidine Kinase Activation Mechanisms from the Monomeric Blue Light Sensor EL346 from ESR and HDX-MS.
Igor Dikiy, Uthama Edupuganti, Rinat Abzalimov, Peter P. Borbat, Madhur Srivastava, Jack H. Freed, and Kevin H. Gardner