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National Biomedical Center
for Advanced Electron Spin Resonance Technology

Our research is supported by a grant from the National Institute of General Medical Sciences (NIGMS), part of the National Institutes of Health.

ACERT Core Research & Development


The principal areas of core R&D carried out at ACERT are
        (click on the underlined text to get the most recent/important information)

Pulsed ESR: Distance Measurements in proteins and aggregates using double quantum coherence (DQC) ESR, to advance our knowledge of structure and function of biomolecules using longer distance constraints, provided by site-directed spin labeling and pulsed ESR distance measurements. Highlights.

Pulsed ESR: pulsed 2D Fourier transform ESR , to further develop 2D-ELDOR in the study of the dynamic structure of membranes and of proteins, as well as lipid-protein interactions. Highlights.

High Resolution ESR microscopy , to establish cw and pulse ESR micro-imaging for biomedical studies of tissues, cells and other bio-samples with micron resolution. Highlights.

HFHF ESR: continuous-wave , to further develop quasi-optical techniques for HFHF-ESR to unravel the complex dynamics in biological systems and, especially, to extend high power pulsed ESR to the mm-wave regime, to benefit from the improved orientational resolution and faster .snapshot. feature at higher frequencies. Highlights.

HFHF ESR: time-domain , to further develop quasi-optical techniques for HFHF-ESR to unravel the complex dynamics in biological systems and, especially, to extend high power pulsed ESR to the mm-wave regime, to benefit from the improved orientational resolution and faster .snapshot. feature at higher frequencies. Highlights.

Multifrequency Studies , to advance knowledge of dynamics in proteins, DNA, and membranes by a mixture of multifrequency and multidimensional ESR. Highlights.

Protein Dynamics by NMR Highlights.

Model and Cell Membrane Dynamics by ESR Highlights.

Theory and computational methods , to improve the methods for interpreting multifrequency spectra in terms of powerful algorithms based on the stochastic Liouville equation and on molecular dynamics simulations. Highlights.

ACERT's Collaborative Projects cover a wide range of biomedical research areas, emphasizing the central role that modern ESR methods can play in contemporary biomedical sciences. Highlights.

Recent Highlights Highlights.

Full Highlights Archive Highlights.