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National Biomedical Resource
for Advanced Electron Spin Resonance Spectroscopy

Our research is supported by grant 1R24GM146107 from the National Institute of General Medical Sciences (NIGMS), part of the National Institutes of Health.

  Key publications
Transition Metal and Metalloprotein ESR
Articles:

Study of paramagnetic defect centers in as-grown and annealed TiO2 anatase and rutile nanoparticles by a variable-temperature X-band and high-frequency (236 GHz) EPR
S. K. Misra, S. I. Andronenko, D. Tipikin, J. H. Freed, V. Somani, and O. Prakash.
J. Magn. Magn. Mater. 401, 495-505 (2016)
<doi:10.1016/j.jmmm.2015.10.072>
PMID: 27041794      PMCID: PMC4815036
 

Interaction of Spin-Labeled Lipid Membranes with Transition Metal Ions
B. Dzikovski, V. Livshits, and J.H. Freed
J. Phys. Chem. B 119, 13330-13346 (2015)
Supporting Information
<doi:10.1021/acs.jpcb.5b08165>
PMID: 26490692      PMCID: PMC4762260
 

An Iron-Sulfur Cluster in the Polymerase Domain of Yeast DNA Polymerase ε
R. Jain, E.S. Vanamee, B.G. Dzikovski, A. Buku, R.E. Johnson, L. Prakash, S. Prakash, A.K. Aggarwal.
J. Mol. Biol. 426 301-308 (2014)
Supporting Information
<doi:10.1016/j.jmb.2013.10.015>
PMID: 24144619      PMCID: PMC4061903
 

Copper-Based Pulsed Dipolar ESR Spectroscopy as a Probe of Protein Conformation Linked to Disease States
G.E. Merz, P.P. Borbat, A.J. Pratt, E.D. Getzoff, J.H. Freed, and B.R. Crane.
Biophys. J. 107, 1669-1674 (2014).
Supporting Information
<doi:10.1016/j.bpj.2014.07.068>
PMID: 25296320      PMCID: PMC4190658
 

Dph3 Is an Electron Donor for Dph1-Dph2 in the First Step of Eukaryotic Diphthamide Biosynthesis
M. Dong, X. Su, B. Dzikovski, E.E. Dando, X. Zhu, J. Du, J.H. Freed, and H. Lin.
J. Am. Chem. Soc. 136, 1754-1757 (2014).
Supporting Information
<doi:10.1021/ja4118957>
PMID: 24422557      PMCID: PMC3985478
 

Mechanistic Understanding of Pyrococcus horikoshii Dph2, a [4Fe-4S] Enzyme Required for Diphthamide Biosynthesis
X. Zhu, B. Dzikovski, X. Su, A.T. Torelli, Y. Zhang, S.E. Ealick, J.H. Freed and H. Lin.
Mol. Biosyst. 7, 74-81 (2011).
<doi:10.1039/c0mb00076k>
PMID: 20931132      PMCID: PMC3066188
 

Joint Analysis of ESR Lineshapes and 1H NMRD Profiles of DOTA-Gd Derivatives by Means of the Slow Motion Theory
D. Kruk, J. Kowalewski, D.S. Tipikin, J.H. Freed, M. Mościcki, A. Mielczarek, and M. Port.
J. Chem. Phys. 134, 024508 (2011).
<doi:10.1063/1.3516590>
PMID: 21241121      PMCID: PMC3188623
 

A Multifrequency EPR Study of Fe2+ and Mn2+ Ions in a ZnSiF6·6H2O Single Crystal at Liquid-Helium Temperatures
S.K. Misra, S. Diehl, D. Tipikin, J.H. Freed.
J. Magn. Res. 205, 14-22 (2010).
<doi:10.1016/j.jmr.2010.03.013>
PMID: 20395160      PMCID: PMC2885525
 

Diphthamide Biosynthesis Requires an Organic Radical Generated by an Iron-Sulphur Enzyme
Y. Zhang, X. Zhu, A.T. Torelli, M. Lee, B. Dzikovski, R.M. Koralewski, E. Wang, J.H. Freed, C. Krebs, S.E. Ealick, and H. Lin.
Nature, 465, 891-896 (2010).
Supporting Information
<doi:10.1038/nature09138>
PMID: 20559380      PMCID: 20592036
 

A 236 GHz Fe3+ EPR Study of Nanoparticles of the Ferromagnetic Room-Temperature Semiconductor Sn1-xFexO2 (x = 0.005)
S.K. Misra, S.I. Andronenko, A. Punnoose, D. Tipikin, and J.H. Freed.
Appl. Magn. Reson. 36, 291-295 (2009).
<doi:10.1007/s00723-009-0024-4>
PMID: 20161547      PMCID: PMC2805097