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National Biomedical Resource
for Advanced Electron Spin Resonance Spectroscopy

Our research is supported by grant 1R24GM146107 from the National Institute of General Medical Sciences (NIGMS), part of the National Institutes of Health.

  Key publications
ACERT Full Publications Archive
Articles:

Structural Dynamics by NMR in the Solid State: II. The MOMD Perspective of the Dynamic Structure of Metal-Organic Frameworks Comprising Several Mobile Components
E. Meirovitch, Z. Liang, R. W. Schurko, S. J. Loeb, and J. H. Freed.
J. Phys. Chem. B 126, 2452-2465 (2022)
<doi:10.1021/acs.jpcb.1c10120>
PMID: 35333061      PMCID: PMC9055879
 

 

Membrane Binding Induces Distinct Structural Signatures in the Mouse Complexin-1C-Terminal Domain
E. M. Grasso, M. S. Terakawa, A. L. Lai, Y. X. Xie, T. F. Ramlall, J. H. Freed, and D. Eliezer.
J. Mol. Biol. 435, 167710 (2023)
<doi:10.1016/j.jmb.2022.167710>
PMID: 35777466      PMCID: PMC9794636
 

 

The N-Terminal Domain of AΒ40-Amyloid Fibril: The MOMD Perspective of its Dynamic Structure from NMR Lineshape Analysis
E. Meirovitch, Z. Liang, and J. H. Freed.
J. Phys. Chem. B 126, 1202-1211 (2022)
<doi:10.1021/acs.jpcb.1c10131>
PMID: 35128920      PMCID: PMC8908910
 

 

Negatively charged residues in the membrane ordering activity of SARS-CoV-1 and -2 fusion peptides
A.L. Lai and J.H. Freed
Biophys. J. 121, 207-227 (2022)
Supporting Information
<doi:10.1016/j.bpj.2021.12.024>
PMID: 34929193      PMCID: PMC8683214
 

Benchmark Test and Guidelines for DEER/PELDOR Experiments on Nitroxide-Labeled Biomolecules
O. Schiemann, C. A. Heubach, D. Abdullin, K. Ackermann, M. Azarkh, E. G. Bagryanskaya, M. Drescher, B. Endeward, J. H. Freed, L. Galazzo, D. Goldfarb, T. Hett, L. Esteban Hofer, L. Fábregas Ibáñez, E. J. Hustedt, S. Kucher, I. Kuprov, J. E. Lovett, A. Meyer, S. Ruthstein, S. Saxena, S. Stoll, C. R. Timmel, M. Di Valentin, H. S. Mchaourab, T. F. Prisner, B. E. Bode, E. Bordignon, M. Bennati, and G. Jeschke.
J. Am. Chem. Soc. 143, 17875-17890 (2021)
Supporting Information
<doi:10.1021/jacs.1c07371>
PMID: 34664948      PMCID: [None -- Not NIH Funded]
 

Highly Basic Clusters in the Herpes Simplex Virus 1 Nuclear Egress Complex Drive Membrane Budding by Inducing Lipid Ordering
M. K. Thorsen, A. Lai, D. P. Hoogerheide, G. C. L. Wong, J. H. Freed, and E. E. Heldwein.
mBio 12 e0154821 (2021)
<doi:10.1128/mBio.01548-21>
PMID: 34425706      PMCID: PMC8406295
 

Theory and Least Squares Fitting of CW ESR Saturation Spectra Using the MOMD Model
P. Gupta, B. Dzikovski, and J. H. Freed
Appl. Magn. Reson. 53 699-715 (2021)
<doi:10.1007/s00723-021-01390-7>
PMID: 35431460      PMCID: PMC9012167
 

 

Dph3 Enables Aerobic Diphthamide Biosynthesis by Donating One Iron Atom to Transform a [3Fe-4S] to a [4Fe-4S] Cluster in Dph1-Dph2
Y. Zhang, D. Su, B. Dzikovski, S. H. Majer, R. Coleman, S. Chandrasekaran, M. K. Fenwick, B. R. Crane, K. M. Lancaster, J. H. Freed, and H. Lin.
J. Am. Chem. Soc. 143, 9314-9319 (2021)
Supporting Information
<doi:10.1021/jacs.1c03956>
PMID: 34154323      PMCID: PMC8251694
 

Extraction of Weak Spectroscopic Signals with High Fidelity: Examples from ESR
M. Srivastava, B. Dzikovski, and J. H. Freed.
J. Phys. Chem. A 125, 4480-4487 (2021)
Supporting Information
<doi:10.1021/acs.jpca.1c02241>
PMID: 34009996      PMCID: PMC8317606
 

SARS-CoV-2 Fusion Peptide has a Greater Membrane Perturbating Effect than SARS-CoV with Highly Specific Dependence on Ca2+
A. L. Lai and J. H. Freed.
J. Mol. Biol. 433, 166946 (2021)
<doi:10.1016/j.jmb.2021.166946>
PMID: 33744314      PMCID: PMC7969826
 

Microsecond dynamics in proteins by two-dimensional ESR. II. Addressing computational challenges
P. Gupta, K. Chaudhari, and J. H. Freed.
J. Chem. Phys. 154, 084115 (2021)
Supporting Information
<doi:10.1063/5.0042441>
PMID: 33639766      PMCID: PMC7928224
 

Microsecond Exchange Processes Studied by Two-Dimensional ESR at 95 GHz
B. Dzikovski, V. V. Khramtsov, S. Chandrasekaran, C. Dunnam, M. Shah, and J. H. Freed.
J. Am. Chem. Soc. 142, 21368-21381 (2020)
Supporting Information
<doi:10.1021/jacs.0c09469>
PMID: 33305945      PMCID: PMC7810061
 

Engineered chemotaxis core signaling units indicate a constrained kinase-off state
A. R. Muok, T. K. Chua, M. Srivastava, W. Yang, Z. Maschmann, P. P. Borbat, J. Chong, S. Zhang, J. H. Freed, A. Briegel, B. R. Crane.
Sci. Signal. 13, eabc1328 (2020)
Supporting Information
<doi:10.1126/scisignal.abc1328>
PMID: 33172954      PMCID: PMC7790435
 

Structural Dynamics by NMR in the Solid State: The Unified MOMD Perspective Applied to Organic Frameworks with Interlocked Molecules
E. Meirovitch, Z. Liang, and J. H. Freed.
J. Phys. Chem. B 124, 6225-6235 (2020)
Supporting Information
<doi:10.1021/acs.jpcb.0c03687>
PMID: 32584038      PMCID: PMC7666760
 

Conformational Dynamics in Extended RGD-Containing Peptides
W. R. Lindemann, A. J. Mijalis, J. L. Alonso, P. P. Borbat, J. H. Freed, M. A. Arnaout, B. L. Pentelute, and J. H. Ortony.
Biomacromolecules 21, 2786-2794 (2020)
Supporting Information
<doi:10.1021/acs.biomac.0c00506>
PMID: 32469507      PMCID: PMC7388056
 

Microsecond dynamics in proteins by two-dimensional ESR: Predictions
P. Gupta, Z. Liang, and J. H. Freed.
J. Chem. Phys. 152, 214112 (2020)
Supporting Information
<doi:10.1063/5.0008094>
PMID: 32505151      PMCID: PMC7863697
 

George K. Fraenkel, Electron Spin Resonance Pioneer
J.H. Freed.
In Pioneers of Magnetic Resonance. Strom, E. T., Mainz, V. V., Eds.   American Chemical Society: Washington, DC, ACS Symposium Series, 2020; Volume 1349, Chapter 8, pp. 137-154.
<doi:10.1021/bk-2020-1349.ch008>
PMID: None-book      PMCID: None-book
 

 

High-yield production in E. coli and characterization of full-length functional p13II protein from human T-cell leukemia virus type 1
E. R. Georgieva, P. P. Borbat, C. Fanouraki, J. H. Freed.
Protein Expr. Purif. 173, 105659 (2020)
Supporting Information
<doi:10.1016/j.pep.2020.105659>
PMID: 32360379      PMCID: PMC7266171
 

Ca2+ Ions Promote Fusion of Middle East Respiratory Syndrome Coronavirus with Host Cells and Increase Infectivity
M. R. Straus, T. Tang, A. L. Lai, A. Flegel, M. Bidon, J. H. Freed, S. Daniel, G. R. Whittaker.
J. Virol. 94, e00426-20 (2020)
Supporting Information
<doi:10.1128/JVI.00426-20>
PMID: 32295925      PMCID: PMC7307142
 

Calcium Ions Directly Interact with the Ebola Virus Fusion Peptide To Promote Structure-Function Changes That Enhance Infection
L. Nathan, A. L. Lai, J. K. Millet, M. R. Straus, J. H. Freed, G. R. Whittaker, and S. Daniel.
ACS Infect. Dis. 6, 250-260 (2020)
Supporting Information
<doi:10.1021/acsinfecdis.9b00296>
PMID: 31746195      PMCID: PMC7040957
 

Local ordering and dynamics in anisotropic media by magnetic resonance: from liquid crystals to proteins
E. Meirovitch & J. H. Freed.
Liq. Cryst. 47, 1926-1954 (2020)
<doi:10.1080/02678292.2019.1622158>
PMID: 32435078      PMCID: PMC7239324
 

The asymmetric function of Dph1–Dph2 heterodimer in diphthamide biosynthesis
M. Dong, E. E. Dando, I. Kotliar, X. Su, B. Dzikovski, J. H. Freed, and H. Lin.
J. Biol. Inorg. Chem. 24, 777-782 (2019)
<doi:10.1007/s00775-019-01702-0>
PMID: 31463593      PMCID: PMC6893874
 

Insights into histidine kinase activation mechanisms from the monomeric blue light sensor EL346
I. Dikiy, U. R. Edupuganti, R. R. Abzalimov, P. P. Borbat, M. Srivastava, J. H. Freed, and K. H. Gardner.
Proc. Natl. Acad. Sci. 116, 4963-4972 (2019)
Supporting Information
<doi:10.1073/pnas.1813586116>
PMID: 30808807      PMCID: PMC6421462
 

Comment on "Distinct Populations in Spin-Label EPR Spectra from Nitroxides."
E. Meirovitch, B. Dzikovski, and J. H. Freed.
J. Phys. Chem. B 123, 2454-2456 (2019)
Supporting Information
<doi:10.1021/acs.jpcb.8b07730>
PMID: 30768266      PMCID: PMC6497408
 

Singular Value Decomposition Method To Determine Distance Distributions in Pulsed Dipolar Electron Spin Resonance: II. Estimating Uncertainty
M. Srivastava and J. H. Freed.
J. Phys. Chem. A 123, 359-370 (2019)
Supporting Information
<doi:10.1021/acs.jpca.8b07673>
PMID: 30525624      PMCID: PMC6372347
 

Cofactors are essential constituents of stable and seeding-active tau fibrils
Y. Fichou, Y. Lin, J. N. Rauch, M. Vigers, Z. Zeng, M. Srivastava, T. J. Keller, J. H. Freed, K. S. Kosik, and S. Han.
Proc. Natl. Acad. Sci. 115, 13234-13239 (2018)
Supporting Information
<doi:10.1073/pnas.1810058115>
PMID: 30538196      PMCID: PMC6310788
 

Phenyl-Ring Dynamics in Amyloid Fibrils and Proteins: The Microscopic-Order-Macroscopic-Disorder Perspective
E. Meirovitch, Z. Liang, and J. H. Freed.
J. Phys. Chem. B 122, 8675-8684 (2018)
Supporting Information
<doi:10.1021/acs.jpcb.8b06330>
PMID: 30141954      PMCID: PMC6174686
 

A facile approach for the in vitro assembly of multimeric membrane transport proteins
E. A. Riederer, P. J. Focke, E. R. Georgieva, N. Akyuz, K. Matulef, P. P. Borbat, J. H. Freed, S. C. Blanchard, O. Boudker, and F. I. Valiyaveetil.
eLife 7, e36478 (2018)
Supporting Information
<doi:10.7554/eLife.36478>
PMID: 29889023      PMCID: PMC6025958
 

Open and Closed Form of Maltose Binding Protein in Its Native and Molten Globule State As Studied by Electron Paramagnetic Resonance Spectroscopy
B. Selmke, P. P. Borbat, C. Nickolaus, R. Varadarajan, J. H. Freed, and W. E. Trommer.
Biochemistry 57, 5507-5512 (2018)
Supporting Information
<doi:10.1021/acs.biochem.8b00322>
PMID: 30004675      PMCID: PMC6211580
 

Site-Specific Incorporation of a Cu2+ Spin Label into Proteins for Measuring Distances by Pulsed Dipolar Electron Spin Resonance Spectroscopy
G. E. Merz, P. P. Borbat, A. R. Muok, M. Srivastava, D. N. Bunck, J. H. Freed, and B. R. Crane.
J. Phys. Chem. B 122, 9443-9451 (2018)
Supporting Information
<doi:10.1021/acs.jpcb.8b05619>
PMID: 30222354      PMCID: PMC6215709
 

MOMD Analysis of NMR Line Shapes from AΒ-Amyloid Fibrils: A New Tool for Characterizing Molecular Environments in Protein Aggregates
E. Meirovitch, Z. Liang, and J. H. Freed.
J. Phys. Chem. B 122, 4793-4801 (2018)
Supporting Information
<doi:10.1021/acs.jpcb.8b02181>
PMID: 29624402      PMCID: PMC5945340
 

Structural basis for membrane anchoring and fusion regulation of the herpes simplex virus fusogen gB
R. S. Cooper, E. R. Georgieva, P. P. Borbat, J. H. Freed, and E. E. Heldwein.
Nat. Struct. Mol. Biol. 25, 416-424 (2018)
Supporting Information
<doi:10.1038/s41594-018-0060-6>
PMID: 29728654      PMCID: PMC5942590
 

Organometallic and radical intermediates reveal mechanism of diphthamide biosynthesis
M. Dong, V. Kathiresan, M. K. Fenwick, A. T. Torelli, Y. Zhang, J. D. Caranto, B. Dzikovski, A. Sharma, K. M. Lancaster, J. H. Freed, S. E. Ealick, B. M. Hoffman, and H. Lin.
Science 359, 1247-1250 (2018)
Supporting Information
<doi:10.1126/science.aao6595>
PMID: 29590073      PMCID: PMC6066404
 

Protein dynamics in the solid-state from 2H NMR lineshape analysis. III. MOMD in the presence of Magic Angle Spinning
E. Meirovitch, Z. Liang, J. H. Freed.
Solid State Nucl. Magn. Reson. 89, 35-44 (2018)
<doi:10.1016/j.ssnmr.2017.11.001>
PMID: 29208317      PMCID: PMC5772661
 

Synthesis and Solution-Phase Characterization of Sulfonated Oligothioetheramides
J. S. Brown, Y. M. Acevedo, G. D. He, J. H. Freed, P. Clancy, and C. A. Alabi.
Macromolecules 50, 8731-8738 (2017)
Supporting Information
<doi:10.1021/acs.macromol.7b01915>
PMID: 29386690      PMCID: PMC5788177
 

Dipolar Spectroscopy — Single–Resonance Methods
P. P. Borbat and J. H. Freed.
In EPR Spectroscopy: Fundamentals and Methods. D. Goldfarb, and S. Stoll, Eds. 139, 15530-15538 (2017)
Wiley & Sons: Chichester, UK.
<doi:10.1002/9780470034590.emrstm1519>
PMID: [None - Book]      PMCID: [None - Book]
 

Singular Value Decomposition Method to Determine Distance Distributions in Pulsed Dipolar Electron Spin Resonance
M. Srivastava and J. H. Freed.
J. Phys. Chem. Lett. 8, 5648-5655 (2017)
Supporting Information
<doi:10.1021/acs.jpclett.7b02379>
PMID: 29099190      PMCID: PMC5708871
 

Design of Hydrated Porphyrin–Phospholipid Bilayers with Enhanced Magnetic Resonance Contrast
S. Shao, T. N. Do, A. Razi, U. Chitgupi, J. Geng, R. J. Alsop, B. G. Dzikovski, M. C. Rheinstädter, J. Ortega, M. Karttunen, J. A. Spernyak, and J. F. Lovell.
Small 13, 1602505 (2017).
Supporting Information
<doi:10.1002/smll.201602505>
PMID: 27739249      PMCID: PMC5209247
 

The SARS–CoV Fusion Peptide Forms an Extended Bipartite Fusion Platform that Perturbs Membrane Order in a Calcium–Dependent Manner
A. L. Lai, J. K. Millet, S. Daniel, J. H. Freed, and G. R. Whittaker.
J. Mol. Biol. 429, 3875-3892 (2017)
<doi:10.1016/j.jmb.2017.10.017>
PMID: 29056462      PMCID: PMC5705393
 

Mechanistic Insight into the Photocontrolled Cationic Polymerization of Vinyl Ethers
Q. Michaudel, T. Chauviré, V. Kottisch, M. J. Supej, K. J. Stawiasz, L. Shen, W. R. Zipfel, H. D. Abruña, J. H. Freed, and B. P. Fors.
J. Am. Chem. Soc. 139, 15530-15538 (2017)
Supporting Information
<doi:10.1021/jacs.7b09539>
PMID: 28985061      PMCID: PMC5806523
 

Unique Structural Features of Membrane–Bound C–Terminal Domain Motifs Modulate Complexin Inhibitory Function
D. Snead, A. L. Lai, R. T. Wragg, D. A. Parisotto, T. F. Ramlall, J. S. Dittman, J. H. Freed, and D. Eliezer.
Front. Mol. Neurosci. 10, 154 (2017)
Supporting Information
<doi:10.3389/fnmol.2017.00154>
PMID: 28596722      PMCID: PMC5442187
 

Substrate–Dependent Cleavage Site Selection by Unconventional Radical S–Adenosylmethionine Enzymes in Diphthamide Biosynthesis
M. Dong, M. Horitani, B. Dzikovski, J. H. Freed, S. E. Ealick, B. M. Hoffman, and H. Lin.
J. Am. Chem. Soc. 139, 5680-5683 (2017)
Supporting Information
<doi:10.1021/jacs.7b01712>
PMID: 28383907      PMCID: PMC5664936
 

Key features of an Hsp70 chaperone allosteric landscape revealed by ion–mobility native mass spectrometry and double electron–electron resonance
A. L. Lai, E. M. Clerico, M. E. Blackburn, N. A. Patel, C. V. Robinson, P. P. Borbat, J. H. Freed, and L. M. Gierasch.
J. Biol. Chem. 292, 8773-8785 (2017)
Supporting Information
<doi:10.1074/jbc.M116.770404>
PMID: 28428246      PMCID: PMC5448104
 

A New Wavelet Denoising Method for Experimental Time–Domain Signals: Pulsed Dipolar Electron Spin Resonance
M. Srivastava, E. R. Georgieva, and J. H. Freed.
REFERENCE
Supporting Information
<doi:DOI>
PMID: PMID      PMCID: PMCID
 

Stability and Conformation of a Chemoreceptor HAMP Domain Chimera Correlates with Signaling Properties
N. Sukomon, J. Widom, P. P. Borbat, J. H. Freed, and B. R. Crane.
Biophys. J. 112, 1383-1395 (2017)
Supporting Information
<doi:10.1016/j.bpj.2017.02.037>
PMID: 28402881      PMCID: PMC5390053
 

Structure-Function Studies Link Class II Viral Fusogens with the Ancestral Gamete Fusion Protein HAP2
J. F. Pinello, A. L. Lai, J. K. Millet, D. Cassidy-Hanley, J. H. Freed, and T. G. Clark.
Curr. Biol. 27, 651-660 (2017)
Supporting Information
<doi:10.1016/j.cub.2017.01.049>
PMID: 28238660      PMCID: PMC5393271
 

Signature of an aggregation-prone conformation of tau
N. A. Eschmann, E. R. Georgieva, P. Ganguly, P. P. Borbat, M. D. Rappaport, Y. Akdogan, J. H. Freed, J. -E. Shea, and S. Han.
Sci. Rep. 7, 44739 (2017)
Supporting Information
<doi:10.1038/srep44739>
PMID: 28303942      PMCID: PMC5356194
 

Bacterial Energy Sensor Aer Modulates the Activity of the Chemotaxis Kinase CheA Based on the Redox State of the Flavin Cofactor
D. Samanta, J. Widom, P. P. Borbat, J. H. Freed, and B. R. Crane.
J. Biol. Chem. 291, 25809-25814 (2016)
<doi:10.1074/jbc.C116.757492>
PMID: 27803157      PMCID: PMC5207056
 

Organometallic Complex Formed by an Unconventional Radical S-Adenosylmethionine Enzyme
M. Dong, M. Horitani, B. Dzikovski, M. -E. Pandelia, C. Krebs, J. H. Freed, B. M. Hoffman, and H. Lin.
J. Am. Chem. Soc. 138, 9755-9758 (2016)
Supporting Information
<doi:10.1021/jacs.6b04155>
PMID: 27465315      PMCID: PMC5068486
 

Nitrosomonas europaea cytochrome P460 is a direct link between nitrification and nitrous oxide emission
J. D. Caranto, A. C. Vilbert, and K. M. Lancaster.
Proc. Natl. Acad. Sci. 113, 14704-14709 (2016).
<doi:10.1073/pnas.1611051113>
PMID: 27856762      PMCID: PMC5187719
 

A New Wavelet Denoising Method for Selecting Decomposition Levels and Noise Thresholds
M. Srivastava, C. L. Anderson, and J. H. Freed.
IEEE Access 4 3862-3877 (2016)
<doi:10.1109/ACCESS.2016.2587581>
PMID: 27795877      PMCID: PMC5079185
 

Constraints on the Radical Cation Center of Cytochrome c Peroxidase for Electron Transfer from Cytochrome c
T. M. Payne, E. F. Yee, B. Dzikovski, and B. R. Crane.
Biochemistry 55, 4807-4822 (2016).
<doi:10.1021/acs.biochem.6b00262>
PMID: 27499202      PMCID: PMC5689384
 

Conformational Response of Influenza A M2 Transmembrane Domain to Amantadine Drug Binding at Low pH (pH 5.5)
E. R. Georgieva, P. P. Borbat, K. Grushin, S. Stoilova-McPhie, N. J. Kulkarni, Z. Liang, and J. H. Freed.
Front. Physiol. 7, 317 (2016)
Supporting Information
<doi:10.3389/fphys.2016.00317>
PMID: 27524969      PMCID: PMC4965473
 

Local Ordering at Mobile Sites in Proteins from Nuclear Magnetic Resonance Relaxation: the Role of Site Symmetry
O. Tchaicheeyan, J. H. Freed, and E. Meirovitch.
J. Phys. Chem. B 120 2886-2898 (2016)
Supporting Information
<doi:10.1021/acs.jpcb.6b00524>
PMID: 26938937      PMCID: PMC4837759
 

Study of paramagnetic defect centers in as-grown and annealed TiO2 anatase and rutile nanoparticles by a variable-temperature X-band and high-frequency (236 GHz) EPR
S. K. Misra, S. I. Andronenko, D. Tipikin, J. H. Freed, V. Somani, and O. Prakash.
J. Magn. Magn. Mater. 401, 495-505 (2016)
<doi:10.1016/j.jmmm.2015.10.072>
PMID: 27041794      PMCID: PMC4815036
 

Structural Basis for Activation, Assembly and Membrane Binding of ESCRT-III Snf7 Filaments
S. Tang, W. M. Henne, P. P. Borbat, N. J. Buchkovich, J. H. Freed, Y. Mao, J. C. Fromme, and S. D. Emr.
eLife 4 e12548 (2015)
Supporting Information
<doi:10.7554/eLife.12548>
PMID: 26670543      PMCID: PMC4720517
 

Pulsed Dipolar Spectroscopy Reveals that Tyrosyl Radicals Are Generated in Both Monomers of the Cyclooxygenase-2 Dimer
B. J. Orlando, P. P. Borbat, E. R. Georgieva, J. H. Freed, and M. G. Malkowski.
Biochemistry 54 7309-7312 (2015)
Supporting Information
<doi:10.1021/acs.biochem.5b00979>
PMID: 26636181      PMCID: PMC4707933
 

Protein Dynamics in the Solid State from 2H NMR Line Shape Analysis. II. MOMD Applied to C-D and C-CD3 Probes
E. Meirovitch, Z. Liang, and J. H. Freed.
J. Phys. Chem. B 119 14022-14032 (2015)
<doi:10.1021/acs.jpcb.5b07434>
PMID: 26402431      PMCID: PMC4676681
 

Interaction of Spin-Labeled Lipid Membranes with Transition Metal Ions
B. Dzikovski, V. Livshits, and J.H. Freed
J. Phys. Chem. B 119, 13330-13346 (2015)
Supporting Information
<doi:10.1021/acs.jpcb.5b08165>
PMID: 26490692      PMCID: PMC4762260
 

Signal Transduction in Light-Oxygen-Voltage Receptors Lacking the Adduct-Forming Cysteine Residue
E.F. Yee, R.P. Diensthuber, A.T. Vaidya, P.P. Borbat, C. Engelhard, J.H. Freed, R. Bittl, A. Möglich, and B.R. Crane.
Nature Comm. 6 10079 (2015)
<doi:10.1038/ncomms10079>
PMID: 26648256      PMCID: PMC4682037
 

The Interaction between Influenza HA Fusion Peptide and Transmembrane Domain Affects Membrane Structure
A.L. Lai and J.H. Freed
Biophys. J. 109, 2523-2536 (2015)
<doi:10.1016/j.bpj.2015.10.044>
PMID: 26682811      PMCID: PMC4699882
 

Focus: Two-dimensional electron-electron double resonance and molecular motions: The challenge of higher frequencies
J.M. Franck, S. Chandrasekaran, B. Dzikovski, C.R. Dunnam, and J.H. Freed.
J. Chem. Phys. 142, 212302-212314 (2015).
<doi:10.1063/1.4917322>
PMID: 26049420      PMCID: PMC4443839
 

Preformed Soluble Chemoreceptor Trimers That Mimic Cellular Assembly States and Activate CheA Autophosphorylation
A.R. Greenswag, X. Li, P.P. Borbat, D. Samanta, K.J. Watts, J.H. Freed, and B.R. Crane
Biochemistry 54, 3454-3468 (2015).
Supporting Information
<doi:10.1021/bi501570n>
PMID: 25967982      PMCID: PMC4772074
 

Mechanism of Influenza A M2 Transmembrane Domain Assembly in Lipid Membranes
E.R. Georgieva, P.P. Borbat, H.D. Norman, and J.H. Freed
Sci. Rep. 5, 11757 (2015).
Supporting Information
<doi:10.1038/srep11757>
PMID: 26190831      PMCID: PMC4507135
 

Dynamic Nuclear Polarization of Membrane Proteins: Covalently Bound Spin-Labels at Protein-Protein Interfaces
B.J. Wylie, B.G. Dzikovski, S. Pawsey, M. Caporini, M. Rosay, J.H. Freed, A.E. McDermott.
J. Biomol. NMR 61, 361-367 (2015).
<doi:10.007/s10858-015-9919-6>
PMID: 25828256      PMCID: PMC4819240
 

Protein Dynamics in the Solid State from 2H NMR Line Shape Analysis: A Consistent Perspective
E. Meirovitch, Z. Liang, and J.H. Freed.
J. Phys. Chem B 119, 2857-2868 (2015).
<doi:10.1021/jp511386b>
PMID: 25594631      PMCID: PMC4358757
 

Assembly States of FliM and FliG Within the Flagellar Switch Complex
R. Sircar, P.P. Borbat, M.J. Lynch, J. Bhatnagar, M.S. Beyersdorf, C.J. Halkides, J.H. Freed and B.R. Crane.
J. Mol. Biol. 427, 867-886 (2015).
Supporting Information
<doi:10.1016/j.jmb.2014.12.009>
PMID: 25536293      PMCID: PMC4323944
 

Bacterial Chemoreceptor Dynamics Correlate With Activity State and Are Coupled Over Long Distances
D. Samanta, P.P. Borbat, B. Dzikovski, J.H. Freed, and B.R. Crane.
Proc. Natl. Acad. Sci. U. S. A. 112, 2455-2460 (2015).
Supporting Information
<doi:10.1073/pnas.1414155112>
PMID: 25675479      PMCID: PMC4345563
 

Pulse Dipolar ESR of Doubly Labeled Mini TAR DNA and Its Annealing to Mini TAR RNA
Y. Sun, P.P. Borbat, V.M. Grigoryants, W.K. Myers, J.H. Freed, and C.P. Scholes.
Biophys. J. 108, 893-902 (2015).
Supporting Information
<doi:10.1016/j.bpj.2014.12.028>
PMID: 25692594      PMCID: PMC4336369
 

Transport Domain Unlocking Sets the Uptake Rate of an Aspartate Transporter
N. Akyuz, E.R. Georgieva, Z. Zhou, S. Stolzenberg, M.A. Cuendet, G. Khelashvili, R.B. Altman, D.S. Terry, J.H. Freed, H. Weinstein, O. Boudker, and S.C. Blanchard.
Nature 518, 68-73 (2015).
<doi:10.1038/nature14158>
PMID: 25652997      PMCID: PMC4351760
 

A Fluorimetric Readout Reporting the Kinetics of Nucleotide-Induced Human Ribonucleotide Reductase Oligomerization
Y. Fu, H.-Y. Lin, S. Wisitpitthaya, W.A. Blessing and Y. Aye.
Chembiochem 15 2598-2604 (2014)
Supporting Information
<doi:10.1002/cbic.201402368>
PMID: 25256246      PMCID: PMC4271543
 

An Iron-Sulfur Cluster in the Polymerase Domain of Yeast DNA Polymerase ε
R. Jain, E.S. Vanamee, B.G. Dzikovski, A. Buku, R.E. Johnson, L. Prakash, S. Prakash, A.K. Aggarwal.
J. Mol. Biol. 426 301-308 (2014)
Supporting Information
<doi:10.1016/j.jmb.2013.10.015>
PMID: 24144619      PMCID: PMC4061903
 

Tau Binds to Lipid Membrane Surfaces via Short Amphipathic Helices Located in Its Microtubule-Binding Repeats
E.R. Georgieva, S. Xiao, P.P. Borbat, J.H. Freed, and D. Eliezer.
Biophys. J. 107, 1441-1452 (2014).
Supporting Information
<doi:10.1016/j.bpj.2014.07.046>
PMID: 25229151      PMCID: PMC4167292
 

Copper-Based Pulsed Dipolar ESR Spectroscopy as a Probe of Protein Conformation Linked to Disease States
G.E. Merz, P.P. Borbat, A.J. Pratt, E.D. Getzoff, J.H. Freed, and B.R. Crane.
Biophys. J. 107, 1669-1674 (2014).
Supporting Information
<doi:10.1016/j.bpj.2014.07.068>
PMID: 25296320      PMCID: PMC4190658
 

Aggregation Propensities of Superoxide Dismutase G93 Hotspot Mutants Mirror ALS Clinical Phenotypes
A.J. Pratt, D.S. Shin, G.E. Merz, R.P. Rambo, W.A. Lancaster, K.N. Dyer, P.P. Borbat, F.L. Poole II, M.W.W. Adams, J.H. Freed, B.R. Crane, J.A. Tainer, and E.D. Getzoff.
Proc. Natl. Acad. Sci. U. S. A. 111, E4568-E4576 (2014).
<doi:10.1073/pnas.1308531111>
PMID: 25316790      PMCID: PMC4217430
 

Dph3 Is an Electron Donor for Dph1-Dph2 in the First Step of Eukaryotic Diphthamide Biosynthesis
M. Dong, X. Su, B. Dzikovski, E.E. Dando, X. Zhu, J. Du, J.H. Freed, and H. Lin.
J. Am. Chem. Soc. 136, 1754-1757 (2014).
Supporting Information
<doi:10.1021/ja4118957>
PMID: 24422557      PMCID: PMC3985478
 

HIV gp41 Fusion Peptide Increases Membrane Ordering in a Cholesterol-Dependent Fashion
A.L. Lai and J.H. Freed.
Biophys. J. 106, 172-181 (2014).
<doi:10.1016/j.bpj.2013.11.027>
PMID: 24411249      PMCID: PMC3907210
 

Pulse Dipolar Electron Spin Resonance: Distance Measurements
P.P. Borbat and J.H. Freed.
In Structural Information from Spin-Labels and Intrinsic Paramagnetic Centers in the Biosciences. Structure and Bonding. Vol. 152. J. Harmer and C. Timmel, Eds.
Springer: Heidelberg, Germany; New York, USA, 2013; pp. 1-82.
<doi:10.1007/430_2012_82>
PMID: [None - Book]      PMCID: [None - Book]
 

Uncoupling of Allosteric and Oligomeric Regulation in a Functional Hybrid Enzyme Constructed from Escherichia coli and Human Ribonucleotide Reductase
Y. Fu, M.J.C. Long, M. Rigney, S. Parvez, W.A. Blessing, Y. Aye.
Biochemistry 52 7050-7059 (2013)
Supporting Information
<doi:10.1021/bi400781z>
PMID: 24024562     
 

Architecture of the Soluble Receptor Aer2 Indicates an In-Line Mechanism for PAS and HAMP Domain Signaling
M.V. Airola, D. Huh, N. Sukomon, J. Widom, R. Sircar, P.P. Borbat, J.H. Freed, K.J. Watts, and B.R. Crane.
J. Mol. Biol. 425, 886-901 (2013).
Supporting Information
<doi:10.1016/j.jmb.2012.12.011>
PMID: 23274111      PMCID: PMC3577987
 

HAMP Domain Conformers that Propagate Opposite Signals in Bacterial Chemoreceptors
M.V. Airola, N. Sukomon, D. Samanta, P.P. Borbat, J.H. Freed, K.J. Watts, and B.R. Crane.
PLoS Biol. 11, e1001479, (2013).
Supporting Information
<doi:10.1371/journal.pbio.1001479>
PMID: 23424282      PMCID: PMC3570549
 

Improved Sensitivity for Long-Distance Measurements in Biomolecules: Five-Pulse Double Electron-Electron Resonance
P.P. Borbat, E.R. Georgieva, and J.H. Freed.
J. Phys. Chem. Lett. 4, 170-175 (2013).
Supporting Information
<doi:10.1021/jz301788n>
PMID: 23301118      PMCID: PMC3538160
 

Spin Labels in the Gel Phase and Frozen Lipid Bilayers: Do They Truly Manifest a Polarity Gradient?
B. Dzikowski and J.H. Freed.
In Nitroxides-Theory, Experiment and Applications; A. Kokorin. Ed.
InTech: Rijeka, Croatia, 2012; pp. 167-190.
<doi:10.5772/2887>
PMID: [None - Book]      PMCID: [None - Book]
 

The Internal Dynamics of Mini c TAR DNA Probed by Electron Paramagnetic Resonance of Nitroxide Spin-Labels at the Lower Stem, the Loop, and the Bulge
Y. Sun, Z. Zhang, V.M. Grigoryants, W.K. Myers, F. Liu, and K. Earle, J.H. Freed, C.P. Scholes
Biochemistry 51, 8530-8541 (2012).
Supporting Information
<doi:10.1021/bi301058q>
PMID: 23009298      PMCID: PMC3549007
 

Conformational Ensemble of the Sodium-Coupled Aspartate Transporter
E.R. Georgieva, P.P. Borbat, C. Ginter, J.H. Freed, and O. Boudker.
Nat. Struct. Mol. Biol. 20, 215-221 (2013).
Supporting Information
<doi:10.1038/nsmb.2494>
PMID: 23334289      PMCID: PMC3565060
 

Locating a Lipid at the Portal to the Lipoxygenase Active Site
B.J. Gaffney, M. Bradshaw, S. Frausto, F. Wu, J.H. Freed, and P.P. Borbat.
Biophysical J. 103, 2134-2144, (2012).
Supporting Information
<doi:10.1016/j.bpj.2012.10.002>
PMID: 23200047      PMCID: PMC3512035
 

Pulsed ESR Dipolar Spectroscopy for Distance Measurements in Immobilized Spin Labeled Proteins in Liquid Solution
Z. Yang, Y. Liu, P.P. Borbat, J.L. Zweier, J.H. Freed, and W.L. Hubbell.
J. Am. Chem. Soc. 134, 9950-9952 (2012).
Supporting Information
<doi:10.1021/ja303791p>
PMID: 22676043      PMCID: PMC3409244
 

Self-Association of the Histidine Kinase CheA as Studied by Pulsed Dipolar ESR Spectroscopy
J. Bhatnagar, R. Sircar, P.P. Borbat, J.H. Freed, and B.R. Crane.
Biophys. J. 102, 2192-2201 (2012).
Supporting Information
<doi:10.1016/j.bpj.2012.03.038>
PMID: 22824284      PMCID: PMC3341552
 

Dynamics and Ordering of Lipid Spin-Labels Along the Coexistence Curve of Two Membrane Phases: An ESR Study
A.K. Smith and J.H. Freed.
Chem. Phys. Lipids, 165, 348-361 (2012).
Supporting Information
<doi:10.1016/j.chemphyslip.2012.02.009>
PMID: 22586732      PMCID: PMC3526980
 

Conformational Distributions and Hydrogen Bonding in Gel and Frozen Lipid Bilayers: A High Frequency Spin-Label ESR Study
B. Dzikovski, D. Tipikin, and J. Freed
J. Phys. Chem. B, 116, 6694-6706 (2012).
Supporting Information
<doi:10.1021/jp211879s>
PMID: 22324811      PMCID: PMC3376253
 

Effect of Freezing Conditions on Distances and Their Distributions Derived From Double Electron Electron Resonance (DEER): A Study of Doubly-Spin-Labeled T4 Lysozyme
E.R. Georgieva, A.S. Roy, V.M. Grigoryants, P.P. Borbat, K.A. Earle, C.P. Scholes, and J.H. Freed.
J. Magn. Reson. 216, 69-77 (2012).
Supporting Information
<doi:10.1016/j.jmr.2012.01.004>
PMID: 22341208      PMCID: PMC3323113
 

A Protocol for Detecting and Scavenging Gas-phase Free Radicals in Mainstream Cigarette Smoke
L.X. Yu, B.G. Dzikovski, and J.H. Freed.
J. Vis. Exp. 59, e3406 (2012).
<doi:10.3791/3406>
PMID: 22230844      PMCID: PMC3369772
 

Electron Tunneling in Lithium-Ammonia Solutions Probed by Frequency-Dependent Electron Spin Relaxation Studies
K. Maeda, M.T.J. Lodge, J. Harmer, J.H. Freed, and P.P. Edwards.
J. Am. Chem. Soc. 134, 9209-18 (2012).
<doi:10.1021/ja212015b>
PMID: 22568866      PMCID: PMC3415590
 

Membrane Fluidity
B. Dzikovski and J.H. Freed.
In Encyc. Biophys.; G.C.K. Roberts, Ed.
Springer Verlag: Berlin, Germany, 2013; pp 1440-1446.
<doi:10.1007/978-3-642-16712-6_546>
PMID: [None - Book]      PMCID: [None - Book]
 

Stochastic Methods for Magnetic Resonance Spectroscopies
A. Polimeno, V. Barone, and J.H. Freed.
In Computational Strategies for Spectroscopy: From Small Molecules to Nano Systems; V. Barone, Ed.
Wiley: New York, NY, 2012; Chapter 12.
PMID: [None - Book]      PMCID: [None - Book]
 

Protein Dynamics by NMR Spin Relaxation: The Slowly Relaxing Local Structure Perspective
E. Meirovitch, A. Polimeno, and J.H. Freed.
In E. Mag. Res. Online, R.K. Harris and R.L. Wasylishen, Eds.
John Wiley & Sons, Inc.: New York, 2011; pp 1-9.
<doi:10.1002/9780470034590.emrstm1243>
PMID: [None - Book]      PMCID: [None - Book]
 

Distance Measurements: Continuous-Wave (CW)- and Pulsed Dipolar EPR
S.K. Misra and J.H. Freed.
In Multifrequency Electron Paramagnetic Resonance, S.K. Misra, Ed.
Wiley-VCH: New York, 2011; Chapter 12, pp. 545-588.
PMID: [None - Book]      PMCID: [None - Book]
 

Molecular Motions
S.K. Misra and J.H. Freed.
In Multifrequency Electron Paramagnetic Resonance, S.K. Misra, Ed.
Wiley-VCH: New York, 2011; Chapter 11, pp. 497-544.
PMID: [None - Book]      PMCID: [None - Book]
 

2D-ELDOR Study of Heterogeneity and Domain Structure Changes in Plasma Membrane Vesicles upon Cross-Linking of Receptors
Y.-W. Chiang, A.J. Costa-Filho, B. Baird, and J.H. Freed.
J. Phys. Chem. B 115, 10462-10469 (2011).
Supporting Information
<doi:10.1021/jp2016243>
PMID: 21780815      PMCID: PMC3165081
 

Mechanistic Understanding of Pyrococcus horikoshii Dph2, a [4Fe-4S] Enzyme Required for Diphthamide Biosynthesis
X. Zhu, B. Dzikovski, X. Su, A.T. Torelli, Y. Zhang, S.E. Ealick, J.H. Freed and H. Lin.
Mol. Biosyst. 7, 74-81 (2011).
<doi:10.1039/c0mb00076k>
PMID: 20931132      PMCID: PMC3066188
 

A New Lanczos-Based Algorithm for Simulating High-Frequency Two-Dimensional Electron Spin Resonance Spectra
Y.-W. Chiang and J.H. Freed.
J. Chem. Phys. 134, 034112 (2011).
<doi:10.1063/1.3523576>
PMID: 21261335      PMCID: PMC3041155
 

Joint Analysis of ESR Lineshapes and 1H NMRD Profiles of DOTA-Gd Derivatives by Means of the Slow Motion Theory
D. Kruk, J. Kowalewski, D.S. Tipikin, J.H. Freed, M. Mościcki, A. Mielczarek, and M. Port.
J. Chem. Phys. 134, 024508 (2011).
<doi:10.1063/1.3516590>
PMID: 21241121      PMCID: PMC3188623
 

Methyl Dynamics of a Ca2+-Calmodulin-Peptide Complex from NMR/SRLS
Y.E. Shapiro, A. Polimeno, J.H. Freed, and E. Meirovitch.
J. Phys. Chem. B 115, 354-365 (2011).
<doi:10.1021/jp107130m>
PMID: 21166433      PMCID: PMC3062514
 

ESR Microscopy for Biological and Biomedical Applications
C.S. Shin, C.R. Dunnam, P.P. Borbat, B. Dzikovski, E.D. Barth, H.J. Halpern, and J.H. Freed.
Nanoscience & Nanotechnology Letters 3, 561-567 (2011).
<doi:10.1166/nnl.2011.1206>
PMID: 21984955      PMCID: PMC3188420
 

Backbone Dynamics of Deoxy and Carbonmonoxy Hemoglobin by NMR/SRLS
E. Meirovitch, M. Zerbetto, A. Polimeno, and J.H. Freed.
J. Phys. Chem. B 115, 143-157 (2011).
<doi:10.1021/jp107553j>
PMID: 21162544      PMCID: PMC3071157
 

Two Conserved Residues Are Important for Inducing Highly Ordered Membrane Domains by the Transmembrane Domain of Influenza Hemagglutinin
M. Ge and J.H. Freed.
Biophys. J. 100, 90-97 (2011).
Supporting Information
<doi:10.1016/j.bpj.2010.11.014>
PMID: 21190660      PMCID: PMC3010018
 

Channel and Nonchannel Forms of Spin-Labeled Gramicidin in Membranes and Their Equilibria
B.G. Dzikovski, P.P. Borbat, and J.H. Freed.
J. Phys. Chem. B 115, 176-185 (2011).
Supporting Information
<doi:10.1021/jp108105k>
PMID: 21142163      PMCID: PMC3076037
 

The Lipid-Binding Domain of Wild Type and Mutant α-Synuclein: Compactness and Interconversion Between the Broken and Extended Helix Forms
E.R. Georgieva, T.F. Ramlall, P.P. Borbat, J.H. Freed, and D. Eliezer.
J. Biol. Chem. 285, 28261-28274 (2010).
Supporting Information
<doi:10.1074/jbc.M110.157214>
PMID: 20592036      PMCID: PMC2934691
 

Comment on "The Physical Basis of Model-Free Analysis of NMR Relaxation Data from Proteins and Complex Fluids" [J. Chem. Phys. 131, 224507, 2009]
E. Meirovitch, A. Polimeno, and J.H. Freed.
J. Chem. Phys. 132, 207101 (2010).
<doi:10.1063/1.3429599>
PMID: 20515116      PMCID: PMC2887917
 

A Multifrequency EPR Study of Fe2+ and Mn2+ Ions in a ZnSiF6·6H2O Single Crystal at Liquid-Helium Temperatures
S.K. Misra, S. Diehl, D. Tipikin, J.H. Freed.
J. Magn. Res. 205, 14-22 (2010).
<doi:10.1016/j.jmr.2010.03.013>
PMID: 20395160      PMCID: PMC2885525
 

Structure of the Ternary Complex Formed by a Chemotaxis Receptor Signaling Domain, the CheA Histidine Kinase, and the Coupling Protein CheW As Determined by Pulsed Dipolar ESR Spectroscopy
J. Bhatnagar, P.P. Borbat, A.M. Pollard, A.M. Bilwes, J.H. Freed, and B.R. Crane.
Biochemistry, 49, 3824-3841 (2010).
Supporting Information
<doi:10.1021/bi100055m>
PMID: 20355710      PMCID: PMC2873776
 

Structural Dynamics of Bio-Macromolecules by NMR: The Slowly Relaxing Local Structure Approach
E. Meirovitch, Y.E. Shapiro, A. Polimeno, J.H. Freed.
Progress in NMR Spectroscopy, 56, 360-405 (2010).
<doi:10.1016/j.pnmrs.2010.03.002>
PMID: 20625480      PMCID: PMC2899824
 

Multifrequency Electron Spin Resonance Study of the Dynamics of Spin Labeled T4 Lysozyme
Z. Zhang, M.R. Fleissner, D.S. Tipikin, Z. Liang, J.K. Moscicki, K.A. Earle, W.L. Hubbell, and J.H. Freed.
J. Phys. Chem. B, 114, 5503-5521 (2010).
Supporting Information
<doi:10.1021/jp910606h>
PMID: 20361789      PMCID: PMC2865245
 

Diphthamide Biosynthesis Requires an Organic Radical Generated by an Iron-Sulphur Enzyme
Y. Zhang, X. Zhu, A.T. Torelli, M. Lee, B. Dzikovski, R.M. Koralewski, E. Wang, J.H. Freed, C. Krebs, S.E. Ealick, and H. Lin.
Nature, 465, 891-896 (2010).
Supporting Information
<doi:10.1038/nature09138>
PMID: 20559380      PMCID: 20592036
 

Variable Coupling Scheme for High-Frequency Electron Spin Resonance Resonators Using Asymmetric Meshes
D.S. Tipikin, K.A. Earle and J.H. Freed.
Appl. Magn. Reson. 37, 819-832 (2010).
<doi:10.1007/s00723-009-0088-1>
PMID: 20458356      PMCID: PMC2865681
 

Scanned-Probe Detection of Electron Spin Resonance from a Nitroxide Spin Probe
E.W. Moore, S.G. Lee, S.A. Hickman, S.J. Wright, L.E. Harrell, P.P. Borbat, J.H. Freed, and J.A. Marohn.
PNAS 106, 22251-22256 (2009).
Supporting Information
<doi:10.1073/pnas.0908120106>
PMID: 20018707      PMCID: PMC2799694
 

Multifrequency ESR Study of Spin-Labeled Molecules in Inclusion Compounds with Cyclodextrins
B. Dzikovski, D. Tipikin, V. Livshits, K.A. Earle and J.H. Freed.
Phys. Chem. Chem. Phys. 11, 6676-6688 (2009).
Supporting Information
<doi:10.1039/b903490k>
PMID: 19639141      PMCID: PMC2743463
 

Fusion Peptide from Influenza Hemagglutinin Increases Membrane Surface Order: An Electron-Spin Resonance Study
M. Ge and J.H. Freed.
Biophys. J. 96, 4925-4934 (2009).
Supporting Information
<doi:10.1016/j.bpj.2009.04.015>
PMID: 19527651      PMCID: PMC2712059
 

Molecular-Scale Force Measurement in a Coiled-Coil Peptide Dimer by Electron Spin Resonance
S.V. Gullà, G. Sharma, P.Borbat, J.H. Freed, H. Ghimire, M.R. Benedikt, N.L. Holt, G.A. Lorigan, K. Rege, C. Mavroidis, and D.E. Budil.
J. Am. Chem. Soc. 131, 5374-5375 (2009).
Supporting Information
<doi:10.1021/ja900230w>
PMID: 19331323      PMCID: PMC2888838
 

Calculation of Double-Quantum-Coherence Two-dimensional Spectra: Distance Measurements and Orientational Correlations
S.K. Misra, P.P. Borbat, J.H. Freed.
Appl. Magn. Reson. 36, 237-258 (2009).
<doi:10.1007/s00723-009-0023-5>
PMID: 20161423      PMCID: PMC2786184
 

A Scissors Mechanism for Stimulation of SNARE-Mediated Lipid Mixing by Cholesterol
J. Tong, P.P. Borbat, J.H. Freed, and Y.-K. Shin.
PNAS 106, 5141-5146 (2009).
<doi:10.1073/pnas.0813138106>
PMID: 19251653      PMCID: PMC2663986
 

Determination of Tie-Line Fields for Coexisting Lipid Phases: An ESR Study
A.K. Smith and J.H. Freed.
J. Phys. Chem. B 113, 3957-3971 (2009).
<doi:10.1021/jp808412x>
PMID: 19673072      PMCID: PMC2772187
 

Multifrequency Electron Spin Resonance Spectra of a Spin-Labeled Protein Calculated from Molecular Dynamics Simulations
D. Sezer, J.H. Freed, and B. Roux.
J. Am. Chem. Soc. 131, 2597-2605 (2009).
Supporting Information
<doi:10.1021/ja8073819>
PMID: 19191603      PMCID: PMC2763593
 

A 236 GHz Fe3+ EPR Study of Nanoparticles of the Ferromagnetic Room-Temperature Semiconductor Sn1-xFexO2 (x = 0.005)
S.K. Misra, S.I. Andronenko, A. Punnoose, D. Tipikin, and J.H. Freed.
Appl. Magn. Reson. 36, 291-295 (2009).
<doi:10.1007/s00723-009-0024-4>
PMID: 20161547      PMCID: PMC2805097
 

Membrane Fluidity
B. Dzikovski and J.H. Freed.
In Wiley Encyclopedia of Chemical Biology; T. P. Begley and B. A. Baird, Eds.
Wiley; Hoboken, NJ, USA, 2009; Chapter 2.
PMID: [None - Book]      PMCID: [None - Book]
 

Electron Spin Resonance Microscope for Imaging With Micron Resolution
A. Blank, C.R. Dunnam, P.P. Borbat, J.H. Freed.
Patent #7,403,008 B2, July 22, 2008
<doi:US 20060022675 A1>
 

Membrane-Bound α-Synuclein Forms an Extended Helix: Long-Distance Pulsed ESR Measurements Using Vesicles, Bicelles, and Rodlike Micelles
E.R. Georgieva, T.F. Ramlall, P.P. Borbat, J.H. Freed, and D. Eliezer.
J. Am. Chem. Soc. 130, 12856-12857 (2008).
Supporting Information
<doi:10.1021/ja804517m>
PMID: 18774805      PMCID: PMC2626176
 

Using Markov Models to Simulate Electron Spin Resonance Spectra from Molecular Dynamics Trajectories
D. Sezer, J.H. Freed, and B. Roux.
J. Phys. Chem. B 112, 11014-11027 (2008).
<doi:10.1021/jp801608v>
PMID: 18698714      PMCID: PMC2562300
 

Parametrization, Molecular Dynamics Simulation, and Calculation of Electron Spin Resonance Spectra of a Nitroxide Spin Label on a Polyalanine α-Helix
D. Sezer, J.H. Freed, B. Roux.
J. Phys. Chem. B 112, 5755-5767 (2008).
Supporting Information
<doi:10.1021/jp711375x>
PMID: 18412413      PMCID: PMC2766176
 

Simulating Electron Spin Resonance Spectra of Nitroxide Spin Labels from Molecular Dynamics and Stochastic Trajectories
D. Sezer, J.H. Freed, and B. Roux.
J. Chem. Phys. 128, 165106, (2008).
<doi:10.1063/1.2908075>
PMID: 18447510      PMCID: PMC2809671
 

Determination of the Oligomeric States of Human and Rat Monoamine Oxidases in the Outer Mitochondrial Membrane and Octyl β-D-Glucopyranoside Micelles Using Pulsed Dipolar Electron Spin Resonance Spectroscopy
A.K. Upadhyay, P.P. Borbat, J. Wang, J.H. Freed, and D.E. Edmondson.
Biochemistry 47, 1554-1566 (2008).
<doi:10.1021/bi7021377>
PMID: 18198902      PMCID: [accepted before 04/08]
 

Pros and Cons of Pulse Dipolar ESR: DQC and DEER
P.P. Borbat and J.H. Freed.
EPR Newletter 17, 21-33 (2007).
 

An Improved Picture of Methyl Dynamics in Proteins from Slowly Relaxing Local Structure Analysis of 2H Spin Relaxation
E. Meirovitch, Y.E. Shapiro, A. Polimeno, and J.H. Freed.
J. Phys. Chem. B 111, 12865-12875 (2007).
<doi:10.1021/jp072156s>
PMID: 17941658      PMCID: PMC2885794
 

Conformational Motion of the ABC Transporter MsbA Induced by ATP Hydrolysis
P.P. Borbat, K. Surendhran, M. Bortolus, P. Zou, J.H. Freed, H.S. Mchaourab.
PLoS Biology 5, 2211-2219 (2007).
Supporting Information
<doi:10.1371/journal.pbio.0050271>
PMID: 17927448      PMCID: PMC2001213
 

Dynamic Molecular Structure and Phase Diagram of DPPC-Cholesterol Binary Mixtures: A 2D-ELDOR Study
Y.-W. Chiang, A.J. Costa-Filho, and J.H. Freed.
J. Phys. Chem. B 111, 11260-11270 (2007).
Supporting Information
<doi:10.1021/jp0732110>
PMID: 17760438     
 

Rigid Body Refinement of Protein Complexes with Long-Range Distance Restraints from Pulsed Dipolar ESR
J. Bhatnagar, J.H. Freed, and B.R. Crane.
In Two-Component Signaling Systems, Part B, M. Simon, B.R. Crane and A.B. Crane, Eds.
Methods in Enzymology 423, Ch. 4, pp. 117-133 (2007).
<doi:10.1016/S0076-6879(07)23004-6>
PMID: 17609128     
 

Measuring Distances by Pulsed Dipolar ESR Spectroscopy: Spin-Labeled Histidine Kinases
P.P. Borbat and J.H. Freed.
In Two-Component Signaling Systems, Part B, M. Simon, B.R. Crane and A.B. Crane, Eds.
Methods in Enzymology 423, Ch. 3, pp. 52-116 (2007).
<doi:10.1016/S0076-6879(07)23003-4>
PMID: 17609127     
 

2D-ELDOR Using Full Sc- Fitting and Absorption Lineshapes
Y.-W. Chiang, A. Costa-Filho, J.H. Freed.
J. Magn. Reson. 188, 231-245 (2007).
<doi:10.1016/j.jmr.2007.06.014>
PMID: 17681478     
 

Two-Dimensional ELDOR in the Study of Model and Biological Membranes
Y.-W. Chiang, A.J. Costa-Filho, and J.H. Freed.
Appl. Magn. Reson. 31, 375-386 (2007).
 

Characterizing the Structure and Dynamics of Folded Oligomers: Pulsed ESR Studies of Peptoid Helices
A.T. Fafarman, P.P. Borbat, J.H. Freed and K. Kirshenbaum.
Chem. Comm., 377-379 (2007).
<doi:10.1039/b612198e>
PMID: 17220976     
 

Oxygen Effects on the EPR Signals from Wood Charcoals: Experimental Results and the Development of a Model
O.Y. Grinberg, B.B. Williams, A.E. Ruuge, S.A. Grinberg, D.E. Wilcox, H.M. Swartz, and J.H. Freed.
J. Phys. Chem. B 111, 13316-13324 (2007).
<doi:10.1021/jp072656l>
PMID: 17973414     
 

Collective Fluctuations in Ordered Fluids Investigated by Two-Dimensional Electron-Electron Double Resonance Spectroscopy
B. Fresch, D. Frezzato, G.J. Moro, G. Kothe, and J.H. Freed.
J. Phys. Chem. B 110, 24238-24254, (2006).
<doi:10.1021/jp064028u>
PMID: 17125397     
 

Modeling the Effects of Structure and Dynamics of the Nitroxide Side Chain on the ESR Spectra of Spin-Labeled Proteins
F. Tombolato, A. Ferrarini, and J.H. Freed.
J. Phys. Chem. B 110, 26260-26271 (2006).
<doi:10.1021/jp064028u>
PMID: 17181284      PMCID: PMC2885803
 

Dynamics of the Nitroxide Side Chain in Spin-Labeled Proteins
F. Tombolato, A. Ferrarini, and J.H. Freed.
J. Phys. Chem. B 110, 26248-26259 (2006).
<doi:10.1021/jp0629487>
PMID: 17181283      PMCID: PMC2883179
 

Methyl Dynamics in Proteins from NMR Slowly Relaxing Local Structure Spin Relaxation Analysis: A New Perspective
Eva Meirovitch, Antonino Polimeno, and Jack H. Freed.
J. Phys. Chem. B 110, 20615-20628 (2006).
<doi:10.1021/jp061403+>
PMID: 17034251     
 

Inter-Helix Distances in Lysophospholipid Micelle-Bound α-Synuclein from Pulsed ESR Measurements
P. Borbat, T.F. Ramlall, J.H. Freed, and D. Eliezer.
J. Am. Chem. Soc. 128, 10004-05 (2006).
Supporting Information
<doi:10.1021/ja063122l>
PMID: 16881616     
 

Protein Dynamics from NMR: The Slowly Relaxing Local Structure Analysis Compared with Model-Free Analysis
E. Meirovitch, Y.E. Shapiro, A. Polimeno, and J.H. Freed.
J. Phys. Chem. A 110, 8366-8396 (2006).
<doi:10.1021/jp056975t>
PMID: 16821820      PMCID: PMC2758167
 

ESR Microscopy and Nanoscopy with "Induction" Detection
A. Blank and J.H. Freed.
Isr. J. Chem. 46, 423-438 (2006).
 

Two-Pulse Electron Spin Echo Study of Deuterium-Helium Solids
E.P. Bernard, V.V. Khmelenko, E. Vehmanen, P.P. Borbat, J.H. Freed, and D.M. Lee.
Proc. 24th Intl. Conf. on Low Temp. Physics, 372-373 (2006).
 

Pulse Electron Spin Resonance Method for Investigation of Atoms in Impurity-Helium Solids
E.P. Bernard, V.V. Khmelenko, E. Vehmanen, P.P. Borbat, J.H. Freed, and D.M. Lee.
Proc. 24th Intl. Conf. on Low Temp. Physics, 1659-1660 (2006).
 

High-Field ESR on Aligned Membranes: A Simple Method to Record Spectra from Different Membrane Orientations in the Magnetic Field
B. Dzikovski, K. Earle, S. Pachtchenko, J. Freed.
J. Magn. Reson. 179, 273-279 (2006).
<doi:10.1016/j.jmr.2005.12.015>
PMID: 16427793     
 

Reconstruction of the Chemotaxis Receptor-Kinase Assembly
S.-Y. Park, P.P. Borbat, G. Gonzalez-Bonet, J. Bhatnagar, A.M. Pollard, J.H. Freed, A.M. Bilwes & B.R. Crane.
Nat. Struct. Molec. Biol. 13, 400-407 (2006).
Supporting Information
<doi:10.1038/nsmb1085>
PMID: 16622408     
 

Electron Spin Resonance Microscopy Applied to the Study of Controlled Drug Release
A. Blank, J.H. Freed, N.P. Kumar, C.-H. Wang.
J. Cont. Rel. 111, 174-184 (2006).
<doi:10.1016/j.jconrel.2005.11.019>
PMID: 16460828     
 

Coexisting Domains in the Plasma Membranes of Live Cells Characterized by ESR Spectroscopy
M.J. Swamy, L. Ciani, M. Ge, A.K. Smith, D. Holowka, B. Baird, and J.H. Freed.
Biophys. J. 90, 4452-4465 (2006).
Supporting Information
<doi:10.1529/biophysj.105.070839>
PMID: 16565045      PMCID: PMC1471862
 

EPR Distance Measurements Support a Model for Long-Range Radical Initiation in E. coli Ribonucleotide Reductase
M. Bennati, J.H. Robblee, V. Mugnaini, J. Stubbe, J.H. Freed, and P. Borbat.
J. Am. Chem. Soc. 127, 15014-15015 (2005).
<doi:10.1021/ja054991y>
PMID: 16248626     
 

Effects of Finite Pulse Width on Two-Dimensional Fourier Transform Electron Spin Resonance
Z. Liang, R.H. Crepeau, J.H. Freed.
J. Magn. Reson. 177, 247-260 (2005).
<doi:10.1016/j.jmr.2005.07.024>
PMID: 16150620     
 

Maximum Entropy: A Complement to Tikhonov Regularization for Determination of Pair Distance Distributions by Pulsed ESR
Y.-W. Chiang, P.P. Borbat, J.H. Freed.
J. Magn. Reson. 177, 184-196 (2005).
PMID: 16137901     
 

High-Frequency ESR at ACERT
K.A. Earle, B. Dzikovski, W. Hofbauer, J.K. Moscicki and J.H. Freed.
Magn. Reson. Chem. 43, S256-S266 (2005).
<doi:10.1002/mrc.1684>
PMID: 16235203     
 

A Variable Temperature EPR Study of Mn2+-doped NH4Cl0.9I0.1 Single Crystal at 170 GHz: Zero-Field Splitting Parameter and its Absolute Sign
S.K. Misra, S.I. Andronenko, P. Chand, K.A. Earle, S.V. Paschenko, J.H. Freed.
J. Magn. Reson. 174, 265-269 (2005).
<doi:10.1016/j.jmr.2005.02.015>
PMID: 15862243     
 

The Determination of Pair Distance Distributions by Pulsed ESR Using Tikhonov Regularization
Y.-W. Chiang, P.P. Borbat, J.H. Freed.
J. Magn. Reson. 172, 279-295 (2005).
<doi:10.1016/j.jmr.2004.10.012>
PMID: 15649755     
 

New Method for Determining Tie-lines in Coexisting Membrane Phases using Spin-label ESR
Y.-W. Chiang, J. Zhao, J. Wu, Y. Shimoyama, J.H. Freed, and G.W. Feigenson.
Biochim. Biophys. Acta 1668, 99-105 (2005).
<doi:10.1016/j.bbamem.2004.11.010>
PMID: 15670735     
 

ESR and Molecular Dynamics
J.H. Freed.
In Biomedical EPR, Part B: Methodology, Instrumentation and Dynamics, S.S. Eaton, G.R. Eaton, and L.J. Berliner, Eds.
Biological Magnetic Resonance 24, Chapter 9, pp. 239-268 (2005). (Kluwer, NY).
 

Pulsed Three-Dimensional Electron Spin Resonance Microscopy
A. Blank, C.R. Dunnam, P.P. Borbat, and J.H. Freed.
Appl. Phys. Lett. 85, 5430-5432 (2004).
<doi:10.1063/1.1828599>
 

Dynamic Molecular Structure of DPPC-DLPC-Cholesterol Ternary Lipid System by Spin-Label Electron Spin Resonance
Y.-W. Chiang, Y. Shimoyama, G.W. Feigenson, and J.H. Freed.
Biophys. J. 87, 2483-2496 (2004).
<doi:10.1529/biophysj.104.044438>
PMID: 15454445      PMCID: PMC1304668
 

Spin-Labeled Gramicidin A: Channel Formation and Dissociation
B.G. Dzikovski, P.P. Borbat, and J.H. Freed.
Biophys. J. 87, 3504-3517 (2004).
<doi:10.1529/biophysj.104.044305>
PMID: 15326023      PMCID: PMC1304816
 

A Multifrequency Electron Spin Resonance Study of T4 Lysozyme Dynamics Using the Slowly Relaxing Local Structure Model
Z. Liang, Y. Lou, J.H. Freed, L. Columbus and W.L. Hubbell.
J. Phys. Chem. B 108, 17649-17659 (2004).
<doi:10.1021/jp0484837>
 

Enrichment of Endoplasmic Reticulum with Cholesterol Inhibits Sarcoplasmic-Endoplasmic Reticulum Calcium ATPase-2b Activity in Parallel with Increased Order of Membrane Lipids
Y. Li, M. Ge, L. Ciani, G. Kuriakose, E.J. Westover, M. Dura, D.F. Covey, J.H. Freed, F.R. Maxfield, J. Lytton, and I. Tabas.
J. Biol. Chem. 279, 37030-37039 (2004).
<doi:10.1074/jbc.M405195200>
PMID: 15215242     
 

Measurement of Large Distances in Biomolecules Using Double-Quantum Filtered Refocused Electron Spin-Echoes
P.P. Borbat, J.H. Davis, S.E. Butcher, and J.H. Freed.
J. Am. Chem. Soc. 126, 7746-7747 (2004).
<doi:10.1021/ja049372o>
PMID: 15212500     
 

A Three-Dimensional Electron Spin Resonance Microscope
A. Blank, C.R. Dunnam, P.P. Borbat, and J.H. Freed.
Rev. Sci. Instrum. 75, 3050-3061 (2004).
<doi:10.1063/1.1786353>
 

High-Power 95 GHz Pulsed Electron Spin Resonance Spectrometer
W. Hofbauer, K.A. Earle, C.R. Dunnam, J.K. Moscicki, and J.H. Freed.
Rev. Sci. Instrum. 75, 1194-1208 (2004).
<doi:10.1063/1.1710700>
 

The Development of High Field/High Frequency ESR: Historical Overview
J.H. Freed.
In Very High Frequency (VHF) ESR/EPR, O. Grinberg and L.J. Berliner, Eds.
Biological Magnetic Resonance 22, Chapter 2, pp. 19-43 (2004). (Kluwer, NY).
 

High Field ESR: Applications to Protein Structure and Dynamics: HF ESR Protein Structure and Dynamics
K.A. Earle and A.I. Smirnov.
In Very High Frequency (VHF) ESR/EPR, O. Grinberg and L.J. Berliner, Eds.
Biological Magnetic Resonance 22, Chapter 4, pp. 95-143 (2004). (Kluwer, NY).
 

Sample Resonators for Quasioptical EPR: A Practical Guide for Biological Applications
D.E. Budil and K.A. Earle.
In Very High Frequency (VHF) ESR/EPR, O. Grinberg and L.J. Berliner, Eds.
Biological Magnetic Resonance 22, Chapter 11, pp. 353-399 (2004). (Kluwer, NY).
 

High Resolution Electron Spin Resonance Microscopy
A. Blank, C.R. Dunnam, P.P. Borbat, and J.H. Freed.
J. Magn. Reson. 165, 116-127 (2003).
<doi:10.1016/S1090-7807(03)00254-4>
PMID: 14568522     
 

Mode-Coupling SRLS versus Mode-Decoupled Model-Free N-H Bond Dynamics: Mode-Mixing and Renormalization
E. Meirovitch, Y.E. Shapiro, Z. Liang, and J.H. Freed.
J. Phys. Chem. B 107, 9898-9904 (2003).
<doi:10.1021/jp030502>
 

Mode-Coupling Analysis of 15N CSA-15N-1H Dipolar Cross-Correlation in Proteins. Rhombic Potentials at the N-H Bond
E. Meirovitch, Y.E. Shapiro, V. Tugarinov, Z. Liang, and J.H. Freed.
J. Phys. Chem. B 107, 9883-9897 (2003).
<doi:10.1021/jp030501h>
 

Hydration, Structure, and Molecular Interactions in the Headgroup Region of Dioleoylphosphatidyl-Choline Bilayers: An Electron Spin Resonance Study
M. Ge and J.H. Freed.
Biophys. J. 85, 4023-40. (2003).
<doi:10.1016/S0006-3495(03)74816-4>
PMID: 14645091      PMCID: PMC1303703
 

Ordered and Disordered Phases Coexist in Plasma Membrane Vesicles of RBL-2H3 Mast Cells. An ESR Study
M. Ge, A. Gidwani, H.A. Brown, D. Holowka, B. Baird, and J.H. Freed.
Biophys. J. 85, 1278-1288 (2003).
<doi:10.1016/S0006-3495(03)74563-9>
PMID: 12885671      PMCID: PMC1303245
 

End-to-End Correlation for a C-12 Hydrocarbon Chain
S. Wagner, A.A. Nevzorov, J.H. Freed, and R.G. Bryant.
J. Magn. Reson. 160, 161-165 (2003)
<doi:10.1016/S1090-7807(02)00143-X>
PMID: 12615159     
 

Lipid-Gramicidin Interactions: Dynamic Structure of the Boundary Lipid by 2D-ELDOR
A.J. Costa-Filho, R.H. Crepeau, P.P. Borbat, M. Ge, and J. H. Freed.
Biophys. J. 84, 3364-3378 (2003).
<doi:10.1016/S0006-3495(03)70060-5>
PMID: 12719265      PMCID: PMC1302896
 

A 2D-ELDOR Study of the Liquid Ordered Phase in Multilamellar Vesicle Membranes
A.J. Costa-Filho, Y. Shimoyama, and J.H. Freed.
Biophys. J. 84, 2619-2633, (2003).
<doi:10.1016/S0006-3495(03)75067-X>
PMID: 12668470      PMCID: PMC1302828
 

Variable-Frequency EPR Study of Mn2+-Doped NH4Cl0.9I0.1 Single Crystal at 9.6, 36, and 249.9 GHz: Structural Phase Transition
S.K. Misra, S.I. Andronenko, G. Rinaldi, P. Chand, K.A. Earle, and J.H. Freed.
J. Magn. Reson. 160, 131-138, (2003).
<doi:10.1016/S1090-7807(02)00133-7>
PMID: 12615154     
 

Modern ESR Methods in Studies of the Dynamic Structure of Proteins and Membranes
J.H. Freed.
In EPR in the 2lst. Century , A. Kawamori, J. Yamauchi, and H. Ohta, Eds.
Elsevier Science, Amsterdam, Netherlands, 719-730 (2002).
 

Phase Relaxation in a Many-Body System of Diffusing Spins: Slow Motional Limit
A.A. Nevzorov and J.H. Freed.
J. Chem. Phys. 117, 282-287 (2002).
<doi:10.1063/1.1481764>
 

Domain Flexibility in Ligand-Free and Inhibitor-Bound Escherichia coli Adenylate Kinase Based on a Mode-Coupling Analysis of 15N Spin Relaxation
Y.E. Shapiro, E. Kahana, V. Tugarinov, Z. Liang, J.H. Freed, and E. Meirovitch.
Biochemistry 41, 6271-6281 (2002).
Supporting Information
<doi:10.1021/bi012132q>
PMID: 12009888     
 

Protein Structure Determination Using Long-Distance Constraints from Double-Quantum Coherence ESR: Study of T4 Lysozyme
P.P. Borbat, H.S. Mchaourab, and J.H. Freed.
J. Am. Chem. Soc. 124, 5304-5314 (2002).
<doi:10.1021/ja020040y>
PMID: 11996571     
 

A Novel View of Domain Flexibility in E. coli Adenylate Kinase Based on Structural Mode-Coupling 15N NMR Relaxation
V. Tugarinov, Y.E. Shapiro, Z. Liang, J.H. Freed and E. Meirovitch.
J. Mol. Biol. 315, 155-170 (2002).
Supporting Information
<doi:10.1006/jmbi.2001.5231>
PMID: 11779236     
 

Single-Crystal EPR Studies of Transition-Metal Ions in Inorganic Crystals at Very High Frequency
S.K. Misra, S.I. Andronenko, K.A. Earle, J.H. Freed.
Appl. Magn. Reson. 21, 549-561 (2001).
<doi:10.1007/BF03162428>
 

A Multifrequency ESR Study of the Complex Dynamics of Membranes
Y. Lou, M. Ge, and J.H. Freed.
J. Phys. Chem. B 105, 11053-11056 (2001).
<doi:10.1021/jp013226c>
 

A Many-Body Analysis of the Effects of the Matrix Protons and their Diffusional Motion on Electron Spin Resonance Line Shapes and Electron Spin Echoes
A.A. Nevzorov and J.H. Freed.
J. Chem. Phys. 115, 2416-2429 (2001)
<doi:10.1063/1.1382817>
 

Direct-Product Formalism for Calculating Magnetic Resonance Signals in Many-Body Systems of Interacting Spins
A.A. Nevzorov and J.H. Freed.
J. Chem. Phys. 115, 2401-2415 (2001).
<doi:10.1063/1.1382816>
 

A Structural Mode-Coupling Approach to 15N NMR Relaxation in Proteins
V. Tugarinov, Z. Liang, Y.E. Shapiro, J.H. Freed, and E. Meirovitch.
J. Am. Chem. Soc. 123, 3055-3063 (2001).
Supporting Information
<doi:10.1021/ja003803v>
PMID: 11457016     
 

ADP Ribosylation Factor 6 Binding to Phosphatidylinositol 4,5-Bisphosphate-Containing Vesicles Creates Defects in the Bilayer Structure: An Electron Spin Resonance Study
M. Ge, J.S. Cohen, H.A. Brown, and J.H. Freed.
Biophys. J. 81, 994-1005 (2001).
<doi:10.1016/S0006-3495(01)75757-8>
PMID: 11463641      PMCID: PMC1301569
 

Electron Spin Resonance in Studies of Membranes and Proteins
P.P. Borbat, A.J. Costa-Filho, K.A. Earle, J.K. Moscicki, J.H. Freed.
Science 291, 266-269, (2001).
<doi:10.1126/science.291.5502.266>
PMID: 11253218     
 

Segmental Rotational Diffusion of Spin-Labeled Polystyrene in Dilute Toluene Solution by 9 and 250 GHz ESR
J. Pilar, J. Labský, A. Marek, D.E. Budil, K.A. Earle, and J.H. Freed.
Macromolecules 33, 4438-4444 (2000).
<doi:10.1021/ma0002242>
 

New Technologies in Electron Spin Resonance
J.H. Freed.
Annu. Rev. Phys. Chem. 51, 655-689 (2000).
<doi:10.1146/annurev.physchem.51.1.655>
PMID: 11031296     
 

Double Quantum ESR and Distance Measurements
P.P. Borbat and J.H. Freed.
In Distance Measurements in Biological Systems by EPR, L.J. Berliner, S.S. Eaton, and G.R, Eaton, Eds.
Biological Magnetic Resonance 19, Chapter 9, pp. 383-459 (2000). (Kluwer, NY).
 

An Electron Spin Resonance Study of DNA Dynamics Using the Slowly Relaxing Local Structure Model
Z. Liang, J.H. Freed, R.S. Keyes and A.M. Bobst.
J. Phys. Chem. B 104, 5372-5381 (2000).
<doi:10.1021/jp994219f>
 

Dipolar Relaxation in a Many-Body System of Spins of 1/2
A.A. Nevzorov and J.H. Freed.
J. Chem. Phys. 112, 1425-1443 (2000).
<doi:10.1063/1.480709>
 

Spin Relaxation by Dipolar Coupling: From Motional Narrowing to the Rigid Limit
A.A. Nevzorov and J.H. Freed.
J. Chem. Phys. 112, 1413-1424 (2000).
<doi:10.1063/1.480695>
 

Multiple-Quantum ESR and Distance Measurements
P.P. Borbat and J.H. Freed.
Chem. Phys. Lett. 313, 145-154 (1999).
<doi:10.1016/S0009-2614(99)00972-0>
 

An Assessment of the Applicability of Multifrequency ESR to Study the Complex Dynamics of Biomolecules
Z. Liang and J.H. Freed.
J. Phys. Chem. B 103, 6384-6396 (1999).
<doi:10.1021/jp9907746>
 

Electron Spin Resonance Characterization of Liquid Ordered Phase of Detergent Resistant Membranes from RBL-2H3 Cells
M. Ge, K.A. Field, R. Aneja, D. Holowka, B. Baird, and J.H. Freed.
Biophys. J. 77, 925-933 (1999).
<doi:10.1016/S0006-3495(99)76943-2>
PMID: 10423437      PMCID: PMC1300383
 

Quasioptical Hardware for a Flexible FIR-EPR Spectrometer
K.A. Earle and J.H. Freed.
Appl. Magn. Reson. 16, 247-272 (1999).
<doi:10.1007/BF03161937>
 

A Multifrequency Electron Spin Resonance Study of T4 Lysozyme Dynamics
J.P. Barnes, Z. Liang, H.S. Mchaourab, J.H. Freed, and Wayne L Hubbell.
Biophys. J. 76, 3298-3306, (1999).
<doi:10.1016/S0006-3495(99)77482-5>
PMID: 10354455      PMCID: PMC1300299
 

A "Shunt" Fabry-Perot Resonator for High-Frequency Electron Spin Resonance Utilizing a Variable Coupling Scheme
J.P. Barnes and J.H. Freed.
Rev. Sci. Instrum. 69, 3022-3027 (1998).
<doi:10.1063/1.1149050>
 

Millimeter Wave Electron Spin Resonance Using Quasioptical Techniques
K.A. Earle, D.E. Budil, and J.H. Freed.
Adv. Magn. Optical Reson. 19, 253-323 (1996).
<doi:10.1016/S1057-2732(96)80019-2>
 

Nanosecond RF Switch Driver
C. Dunnam.
Patent #5,214,315, May 25, 1993
 

Calculation of ESR Spectra and Related Fokker-Planck Forms by the use of the Lanczos Algorithm
G. Moro and J.H. Freed.
J. Chem. Phys. 74, 3757-3773 (1981).
<doi:10.1063/1.441604>
 

Theory of Slow Tumbling ESR Spectra for Nitroxides
J.H. Freed.
In Spin Labeling Theory and Applications, L.J. Berliner, Ed.
Academic Press: New York, 1976; Chapter 3.